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    APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C [ Felis catus (domestic cat) ]

    Gene ID: 100144583, updated on 2-May-2024

    Summary

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    Gene symbol
    APOBEC3C
    Gene description
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    APOBEC3; APOBEC3CA
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    Genomic context

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    See APOBEC3C in Genome Data Viewer
    Location:
    chromosome: B4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (132502418..132508873)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109501928 Neighboring gene uncharacterized LOC123386743 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3Ca Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_058374.1 Chromosome B4 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of APOBEC3 Lentiviral Restriction Factors in Cats. Troyer RM, et al. Viruses, 2019 Sep 7. PMID 31500260, Free PMC Article
    2. Absence of A3Z3-Related Hypermutations in the env and vif Proviral Genes in FIV Naturally Infected Cats. Cano-Ortiz L, et al. Viruses, 2018 May 31. PMID 29857485, Free PMC Article
    3. Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3. Yoshikawa R, et al. J Virol, 2017 Jun 1. PMID 28331087, Free PMC Article
    4. Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Zhang Z, et al. Retrovirology, 2016 Jul 1. PMID 27368163, Free PMC Article
    5. Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins. Yoshikawa R, et al. Microbiol Immunol, 2016 Apr. PMID 26935128, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of APOBEC3 Lentiviral Restriction Factors in Cats.
      Title: Expression of APOBEC3 Lentiviral Restriction Factors in Cats.
    2. The correlation between APOBEC A3Z3 haplotypes in domestic cats and the frequency of hypermutations in the FIV vif and env genes were assessed.
      Title: Absence of A3Z3-Related Hypermutations in the env and vif Proviral Genes in FIV Naturally Infected Cats.
    3. findings demonstrate that FIV, a pathogenic lentivirus in domestic cats, antagonizes feline APOBEC3 proteins by both Vif and a viral protease.
      Title: Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3.
    4. study identified in feline APOBEC3 residues important for binding of FIV Vif and a unique protein domain insertion (linker)
      Title: Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors.
    5. Non-primate lentiviral Vif being incapable of counteracting a natural host's anti-viral activity mediated via APOBEC3 protein.
      Title: Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins.
    6. Authors show that the Bel2 domain of feline foamy virus Bet is essential for the inactivation of APOBEC3 cytidine deaminase restriction factors.[APOBEC3]
      Title: Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction.
    7. The FFV accessory protein Bet protein binds to cat APOBEC3 proteins. [APOBEC3]
      Title: Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytidine to uridine editing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA dC->dU-editing enzyme APOBEC-3Ca
    Names
    Antiviral cytidine deaminase A3Ca
    apolipoprotein B editing enzyme catalytic polypeptide-like 3C
    probable DNA dC->dU-editing enzyme APOBEC-3C
    NP_001116508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123036.1 → NP_001116508.1  DNA dC->dU-editing enzyme APOBEC-3Ca

      See identical proteins and their annotated locations for NP_001116508.1

      Status: PROVISIONAL

      Source sequence(s)
      EU057981
      UniProtKB/TrEMBL
      A9QGZ8, A9QGZ9
      Conserved Domains (3) summary
      cd01283
      Location:29 → 143
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:132 → 172
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:20 → 189
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      132502418..132508873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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