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APOBEC3Z3 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3 [ Felis catus (domestic cat) ]

Gene ID: 100127022, updated on 2-May-2024

Summary

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Gene symbol
APOBEC3Z3
Gene description
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
A3H; A3Z3; APOBEC3H
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Genomic context

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Location:
chromosome: B4
Exon count:
5
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (132530270..132535555)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (134878275..134880584)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C Neighboring gene DNA dC->dU-editing enzyme APOBEC-3Ca Neighboring gene chromobox 7 Neighboring gene uncharacterized LOC123386846

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins. Kosugi Y, et al. J Virol, 2021 Jun 10. PMID 33762419, Free PMC Article
  2. A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection. Yoshikawa R, et al. J Virol, 2016 Jan 1. PMID 26491161, Free PMC Article
  3. Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction. Chareza S, et al. Virology, 2012 Mar 15. PMID 22265237
  4. Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids. Zielonka J, et al. J Virol, 2010 Jul. PMID 20444897, Free PMC Article
  5. Multiple restrictions of human immunodeficiency virus type 1 in feline cells. Münk C, et al. J Virol, 2007 Jul. PMID 17459941, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins.
    Title: Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins.
  2. It is particularly noteworthy that feline APOBEC3Z3 haplotype V is resistant to feline immunodeficiency virus Vif-mediated degradation and still inhibits vif-proficient viral infection.
    Title: A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection.
  3. The FFV accessory protein Bet protein binds to cat APOBEC3 proteins. [APOBEC3]
    Title: Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA demethylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytidine to uridine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA dC->dU-editing enzyme APOBEC-3H
Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
NP_001106181.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112710.3 → NP_001106181.2  DNA dC->dU-editing enzyme APOBEC-3H

    See identical proteins and their annotated locations for NP_001106181.2

    Status: PROVISIONAL

    Source sequence(s)
    EF173020
    UniProtKB/Swiss-Prot
    A9QA56
    UniProtKB/TrEMBL
    A6MJG9
    Conserved Domains (3) summary
    cd01283
    Location:23 → 125
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:118 → 162
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:12 → 173
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    132530270..132535555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A9QA56.1 GenPept UniProtKB/Swiss-Prot:A9QA56

Gene LinkOut

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