Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition
Summary:
Analysis of A375 melanoma cells harboring the BRAF V600E oncogenic mutation following treatment with the BRAF inhibitor vemurafenib. Results provide insight into the role of the BRAF V600E oncogene in the pathogenesis of melanoma.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Parmenter TJ, Kleinschmidt M, Kinross KM, Bond ST et al. Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov 2014 Apr;4(4):423-33. PMID: 24469106
