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Sinonasal Keratinizing Squamous Cell Carcinoma

MedGen UID:
1752101
•Concept ID:
C5420022
•
Neoplastic Process
Synonym: Nasal Cavity and Paranasal Sinus Keratinizing Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the mucosal epithelium of the nasal cavity or the paranasal sinuses and is characterized by prominent production of keratin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas.
Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR
Am J Surg Pathol 2015 Sep;39(9):1267-74. doi: 10.1097/PAS.0000000000000460. PMID: 26034869Free PMC Article
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma.
Singh L, Ranjan R, Arava S, Singh MK
Ann Diagn Pathol 2014 Oct;18(5):261-5. Epub 2014 Jan 13 doi: 10.1016/j.anndiagpath.2014.01.003. PMID: 25017972
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article

Recent clinical studies

Etiology

Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.
Svajdler M, Nemcova J, Dubinsky P, Metelkova A, Svajdler P, Straka Ľ, Sakar R, Daum O, Michal M, Skalova A, Mezencev R
Neoplasma 2020 Nov;67(6):1456-1463. Epub 2020 Aug 27 doi: 10.4149/neo_2020_200330N332. PMID: 32853018
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data.
Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB
Head Neck Pathol 2020 Sep;14(3):623-629. Epub 2019 Sep 30 doi: 10.1007/s12105-019-01079-1. PMID: 31571045Free PMC Article
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system.
Chernock RD
Head Neck Pathol 2012 Jul;6 Suppl 1(Suppl 1):S41-7. Epub 2012 Jul 3 doi: 10.1007/s12105-012-0373-4. PMID: 22782222Free PMC Article

Diagnosis

A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene.
Bubola J, MacMillan CM, Weinreb I, Witterick I, Swanson D, Zhang L, Antonescu CR, Dickson BC
Head Neck Pathol 2021 Dec;15(4):1284-1288. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01249-6. PMID: 33394379Free PMC Article
Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.
Svajdler M, Nemcova J, Dubinsky P, Metelkova A, Svajdler P, Straka Ľ, Sakar R, Daum O, Michal M, Skalova A, Mezencev R
Neoplasma 2020 Nov;67(6):1456-1463. Epub 2020 Aug 27 doi: 10.4149/neo_2020_200330N332. PMID: 32853018
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Sinonasal Small Round Blue Cell Tumors: An Immunohistochemical Approach.
Rooper LM, Bishop JA
Surg Pathol Clin 2017 Mar;10(1):103-123. Epub 2016 Dec 28 doi: 10.1016/j.path.2016.10.005. PMID: 28153129
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346

Therapy

A morphologic and immunohistochemical study of nasal mucosa in leatherworkers.
Palomba A, Iaia TE, Biancalani M, Conti S, Battista G, Papaleo B, Franchi A
Am J Rhinol 2008 Jul-Aug;22(4):356-60. doi: 10.2500/ajr.2008.22.3201. PMID: 18702897

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.
Svajdler M, Nemcova J, Dubinsky P, Metelkova A, Svajdler P, Straka Ľ, Sakar R, Daum O, Michal M, Skalova A, Mezencev R
Neoplasma 2020 Nov;67(6):1456-1463. Epub 2020 Aug 27 doi: 10.4149/neo_2020_200330N332. PMID: 32853018
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346

Clinical prediction guides

HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data.
Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB
Head Neck Pathol 2020 Sep;14(3):623-629. Epub 2019 Sep 30 doi: 10.1007/s12105-019-01079-1. PMID: 31571045Free PMC Article
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

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