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Paranasal Sinus Keratinizing Squamous Cell Carcinoma

MedGen UID:
353830
•Concept ID:
C1708603
•
Neoplastic Process
Synonym: Keratinizing Paranasal Sinus Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the paranasal sinuses and is characterized by prominent production of keratin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanasal Sinus Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma.
Singh L, Ranjan R, Arava S, Singh MK
Ann Diagn Pathol 2014 Oct;18(5):261-5. Epub 2014 Jan 13 doi: 10.1016/j.anndiagpath.2014.01.003. PMID: 25017972
CANCER OF THE MAXILLARY SINUS. CLINICAL CLASSIFICATION AND MANAGEMENT.
SISSON GA, JOHNSON NE, AMIRI CS
Ann Otol Rhinol Laryngol 1963 Dec;72:1050-9. doi: 10.1177/000348946307200418. PMID: 14088722
Results of treatment of squamous cell carcinoma of the upper jaw and antrum.
ERICH JB, KRAGH LV
Am J Surg 1960 Sep;100:401-6. doi: 10.1016/0002-9610(60)90378-0. PMID: 13820585

Recent clinical studies

Etiology

A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers.
Laforga JB, Othman BK
Rev Esp Patol 2024 Jan-Mar;57(1):67-70. Epub 2023 Oct 28 doi: 10.1016/j.patol.2023.08.002. PMID: 38246714
Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.
Svajdler M, Nemcova J, Dubinsky P, Metelkova A, Svajdler P, Straka Ľ, Sakar R, Daum O, Michal M, Skalova A, Mezencev R
Neoplasma 2020 Nov;67(6):1456-1463. Epub 2020 Aug 27 doi: 10.4149/neo_2020_200330N332. PMID: 32853018
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Undifferentiated malignant neoplasms of the sinonasal tract.
Wenig BM
Arch Pathol Lab Med 2009 May;133(5):699-712. doi: 10.5858/133.5.699. PMID: 19415944

Diagnosis

A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene.
Bubola J, MacMillan CM, Weinreb I, Witterick I, Swanson D, Zhang L, Antonescu CR, Dickson BC
Head Neck Pathol 2021 Dec;15(4):1284-1288. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01249-6. PMID: 33394379Free PMC Article
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Sinonasal Small Round Blue Cell Tumors: An Immunohistochemical Approach.
Rooper LM, Bishop JA
Surg Pathol Clin 2017 Mar;10(1):103-123. Epub 2016 Dec 28 doi: 10.1016/j.path.2016.10.005. PMID: 28153129
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Undifferentiated malignant neoplasms of the sinonasal tract.
Wenig BM
Arch Pathol Lab Med 2009 May;133(5):699-712. doi: 10.5858/133.5.699. PMID: 19415944

Therapy

The evaluation of radiotherapy after incomplete surgery in patients with carcinoma of the maxillary sinus.
Korzeniowski S, Reinfuss M, Skołyszewski J
Int J Radiat Oncol Biol Phys 1985 Mar;11(3):505-9. doi: 10.1016/0360-3016(85)90181-6. PMID: 2982772
Bleomycin: its utilization in the treatment of head and neck cancer.
Bone RC, Byfield JE, Feren AP, Seagren SL
Laryngoscope 1979 Feb;89(2 Pt 1):224-33. doi: 10.1288/00005537-197902000-00005. PMID: 85232
Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study).
Jackson RT, Fitz-Hugh GS, Constable WC
Laryngoscope 1977 May;87(5 Pt 1):726-36. doi: 10.1002/lary.5540870508. PMID: 850451
Appearance of carcinoma following single exposure to a refrigeration ammonia-oil mixture; report of a case and discussion of the role of cocarcinogenesis.
SHIMKIN MB, DE LORIMIER AA, MITCHELL JR, BURROUGHS TP
AMA Arch Ind Hyg Occup Med 1954 Mar;9(3):186-93. PMID: 13137615

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.
Svajdler M, Nemcova J, Dubinsky P, Metelkova A, Svajdler P, Straka Ľ, Sakar R, Daum O, Michal M, Skalova A, Mezencev R
Neoplasma 2020 Nov;67(6):1456-1463. Epub 2020 Aug 27 doi: 10.4149/neo_2020_200330N332. PMID: 32853018
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346

Clinical prediction guides

HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data.
Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB
Head Neck Pathol 2020 Sep;14(3):623-629. Epub 2019 Sep 30 doi: 10.1007/s12105-019-01079-1. PMID: 31571045Free PMC Article
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Human papillomavirus-related carcinomas of the sinonasal tract.
Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH
Am J Surg Pathol 2013 Feb;37(2):185-92. doi: 10.1097/PAS.0b013e3182698673. PMID: 23095507Free PMC Article

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