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| Status |
Public on Jan 06, 2017 |
| Title |
809094 Biomarker Identification in Fracture Healing (experiment #3873 miRNA performed Apr 2011) |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
The specific genes that distinguish normal fracture healing from abnormal healing or nonunion in humans are unknown. This study was an exploratory investigation of peripheral blood from 2 chronic nonunion patients collected perioperatively (pre/post revision surgery) and at 3 months post revision follow up for comparison to Acutely injured subjects and Healthy volunteer cohorts analyzed separately.
We used microarrays to do a global comparison between 2 chronic nonunion patients collected perioperatively (pre/post revision surgery) and at 3 months post revision follow up.
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| Overall design |
Blood was collected into Paxgene blood RNA tubes pre and post operatively during admission for revision surgery in 2 chronic nonunion patients. Blood was collected again at 3 months follow up. We explored the data with Partek Genomics suite using all samples at all time points to identify a panel of genes that is differentially expressed across groups to enable additional biomaker vetting.
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| Contributor(s) |
Mehta S, Horan AD |
| Citation(s) |
31083145 |
| Submission date |
Jan 05, 2017 |
| Last update date |
Jul 18, 2019 |
| Contact name |
Annamarie D Horan |
| E-mail(s) |
horana@pennmedicine.upenn.edu
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| Organization name |
University of Pennsylvania
|
| Department |
Orthopaedic Surgery
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| Lab |
Division of Orthopaedic Trauma
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| Street address |
3737 Market Street, 6th Floor
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA360313 |
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