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| Status |
Public on Jun 01, 2016 |
| Title |
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to determine the activity of TGFβ signaling and the role of this cytokine in subtype affiliation.
Adenoma samples were collected in the Academic Medical Center (AMC), Amsterdam, The Netherlands. Tubular adenomas (TAs) were obtained from familial adenomatous polyposis (FAP) patients and sessile serrated adenomas (SSAs) were collected from serrated polyposis syndrome (SPS) patients.
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| Overall design |
Gene expression was analyzed for 7 sessile serrated adenomas (SSA) and 9 tubular adenomas (TA).
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| Contributor(s) |
Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, Ijspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, Medema J |
| Citation(s) |
27221051 |
| Submission date |
Mar 21, 2016 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Sander Roeland van Hooff |
| Organization name |
AUMC
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| Department |
Center for Experimental and Molecular Medicine (CEMM),
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| Lab |
Laboratory for Experimental Oncology and Radiobiology (LEXOR)
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| Street address |
Meibergdreef 9
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| City |
Amsterdam |
| ZIP/Postal code |
1105 AZ |
| Country |
Netherlands |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE79462 |
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype |
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| Relations |
| BioProject |
PRJNA315877 |
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