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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 25, 2016 |
| Title |
Human neural stem cells transduced with oncogenic elements associated with aggressive medulloblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Human neural stem and progenitor cells transformed with c-MYC, dominant-negative p53, constitutively active AKT and hTERT formed tumors in mice that recapitulated Group 3 medulloblastoma in terms of pathology and expression profile
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| Overall design |
Isogenic model systems and mouse xenografts
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| Contributor(s) |
Hanaford A, Raabe E, Tamayo P |
| Citation(s) |
27012813 |
| Submission date |
Feb 02, 2016 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Pablo Tamayo |
| E-mail(s) |
ptamayo@ucsd.edu
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| Phone |
508-259-0630
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| Organization name |
UCSD
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| Department |
Moores Cancer Center
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| Street address |
3855 Health Sciences Drive MC 0658
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (6)
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| GSM2052660 |
TA_CB (Human cerebellar neural stem cells control hNSC) |
| GSM2052661 |
TA_CB_p53_MYC (hNSC transduced with MYC, dominant-negative TP53) |
| GSM2052662 |
TA_CB_p53_MYC_hT (hNSC transduced with MYC, dominant-negative TP53, hTERT) |
| GSM2052663 |
TA_CB_P53_MYC_hT_AKT (hNSC transduced with MYC, dominant-negative TP53, hTERT, and AKT) |
| GSM2052664 |
TA_CB_P53_MYC_HT_AKT_B_TUMOR (Mouse xenograph from hNSC transduced with MYC, dominant-negative TP53, hTERT, and AKT) |
| GSM2052665 |
TA_CB_P53_MYC_HT_AKT_A_TUMOR (Mouse xenograph from hNSC transduced with MYC, dominant-negative TP53, hTERT, and AKT) |
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| Relations |
| BioProject |
PRJNA310602 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE77475_RAW.tar |
12.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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