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| Status |
Public on Jul 29, 2017 |
| Title |
SAMHD1 degrades nascent DNA at stalled Forks to promote replication restart |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
SAMHD1 is a triphosphohydrolase and a 3'-5' exonuclease that restricts HIV-1 infection in non-cycling cells. It is also mutated in the Aicardi-Goutières Syndrome (AGS) and in different cancers, including chronic lymphotic leukemia. We report herre that SAMHD1 localizes to DNA replication foci during S phase suggesting that it is involved in DNA synthesis. Using microarray analysis, we examine the replication timing program an we show that SAMHD1 regulates the fork progression but also the replication timing program.
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| Overall design |
Two experimen tal condition : shRNA LUC cells (control) versus shRNA SAMHD1 cells
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| Contributor(s) |
Lin Y, Cadoret J, Pasero P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 29, 2016 |
| Last update date |
Jul 30, 2017 |
| Contact name |
Jean-Charles Cadoret |
| E-mail(s) |
jean-charles.cadoret@ijm.fr
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| Organization name |
CNRS/ Université de Paris
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| Street address |
15 rue hélène Brion
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| City |
Paris |
| ZIP/Postal code |
75013 |
| Country |
France |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA310214 |
