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| Status |
Public on Dec 22, 2020 |
| Title |
Chorioamnion after choriodecidual Group B Streptococcal infection |
| Platform organism |
synthetic construct |
| Sample organism |
Macaca nemestrina |
| Experiment type |
Expression profiling by array
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| Summary |
Choriodecidual infection is associated with preterm premature rupture of membranes (pPROM) and preterm birth. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and may be involved in the pathway leading to chorioamnion weakening following infection. The study objective was to determine if a miRNA profile in the chorioamnion is associated with Group B Streptococcal infection and membrane weakening.
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| Overall design |
Ten chronically catheterized pregnant monkeys (Macaca nemestrina) at 118-125 days gestation (term=172 days) received one of two experimental treatments: 1) choriodecidual and intra-amniotic saline infusions (n=5), or 2) GBS choriodecidual inoculation (n=5).
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| Contributor(s) |
Bammler TK, Beyer RP, Vanderhoeven JP, Gravett MG, Adams-Waldorf KM, Rajagopa L, Bierle C, Weed S, Boldenow E, Parker E, Carter WG, Liggitt D, Johnson B |
| Citation(s) |
26284599 |
| Submission date |
Jan 22, 2016 |
| Last update date |
Dec 24, 2020 |
| Contact name |
James William MacDonald |
| E-mail(s) |
jmacdon@uw.edu
|
| Organization name |
University of Washington
|
| Department |
Environmental and Occupational Health Sciences
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| Street address |
4225 Roosevelt Way NE
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98105-6099 |
| Country |
USA |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA309712 |
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