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| Status |
Public on Sep 28, 2018 |
| Title |
Heart Chamber Evolution Reveals Roles of Gene/Genome Duplications on Continuous Character Evolution in Vertebrates |
| Organisms |
Ciona intestinalis; Petromyzon marinus; Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We sequenced at mRNA level in adult hearts of zebrafish, pamprey and sea squirt. Combined with other 11 vertebrate heart RNA-Seq data online, we conducted comprehensive evolutionary genomic analyses to address the contribution of gene/genome duplications on heart structure evolution. We observed that number of duplicate genes expressed in heart increased gradually with the increase of heart chamber number along the vertebrate phylogeny, despite that most of them were duplicated at the time near to the origin of vertebrates or more ancient. Our research provides a clear-cut example to show the relationship among gene duplication, continuous character evolution like heart structure evolution and nature selection.
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| Overall design |
Examination of mRNA levels in thirteen vertebrate samples with different cardiac chamber number, and one invertebrate (sea squirt).
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| Contributor(s) |
Zou Y, Liu G, Shen L, Zhou Z, Sun L, Zhong T, Wang H, Su Z, Gu X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 28, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Gang Biao Liu |
| E-mail(s) |
12210700120@fudan.edu.cn
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| Phone |
86-21-5163-0615
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| Organization name |
Fudan univeristy
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| Department |
School of life science
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| Street address |
2005 Songhu Rd
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| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200433 |
| Country |
China |
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| Platforms (3) |
| GPL14875 |
Illumina HiSeq 2000 (Danio rerio) |
| GPL20962 |
Illumina HiSeq 2000 (Ciona intestinalis) |
| GPL20963 |
Illumina HiSeq 2000 (Petromyzon marinus) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA297221 |
| SRA |
SRP064261 |
