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| Status |
Public on Nov 27, 2007 |
| Title |
High cholesterol diet and phenobarbital affect cholesterol homeostasis and drug metabolism |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A.
Keywords: treatment and diet effects
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| Overall design |
One group of mice was treated 50 mg/kg of phenobarbital in vehicle (5% DMSO in corn oil). Untreated group was injected vehicle only. Third group was 7 days on 1% (w/w) cholesterol diet prior vehicle treatment. After 10 hours animals were sacrificed and total RNA was isolated from liver. Total RNA from two animals was pooled resulting in 4 pools per group. These pools were analyzed using Affymetrix GeneChip MOE430A.
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| Contributor(s) |
Roth A, Loser R, Meyer UA |
| Citation(s) |
18261244 |
| Submission date |
Jan 12, 2007 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Peter Juvan |
| Phone |
+386 1 543 7595
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| Organization name |
Faculty of Medicine, University of Ljubljana
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| Department |
Institute of Biochemistry
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| Lab |
Center for Functional Genomics and Bio-Chips
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| Street address |
Zaloska 4
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| City |
Ljubljana |
| ZIP/Postal code |
SI-1000 |
| Country |
Slovenia |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA98991 |
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