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| Status |
Public on Mar 12, 2015 |
| Title |
Genomic and Clinical Effects Associated with a Relaxation Response Mind-Body Intervention in Patients with Irritable Bowel Syndrome and Inflammatory Bowel Disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Patients with chronic illnesses such as Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD) often have reduced quality of life. IBS is characterized by abdominal pain/discomfort associated with altered bowel function, such as diarrhea or constipation, without gross structural changes or inflammation [1]; IBD is characterized by gross inflammation in the gastrointestinal (GI) tract which can result in symptoms such as abdominal pain, cramping, diarrhea and bloody stools. IBS and IBD can profoundly affect quality of life and are influenced by stress and resiliency.The impact of mind-body interventions (MBIs) on IBS and IBD patients has not previously been examined. In this study IBS and IBD patients were enrolled in a 9-week relaxation response based mind-body group intervention (RR-MBI), focusing on elicitation of the RR and cognitive skill building. We performed Peripheral blood transcriptome analysis to identify genomic correlates of the RR-MBI.
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| Overall design |
This pilot, single center, single-arm, open-label study utilized an RR-MBI for the treatment of IBS and IBD using elicitation of the RR through meditation techniques and cognitive skill building, as established by the Benson-Henry Institute for Mind Body Medicine at the Massachusetts General Hospital (BHI).Blood was collected at baseline and after 9 weeks for transcriptional expression profiling in PAXgene (Qiagen) tubes. Total RNA was isolated from whole blood samples and gene expression profile was assessed on IBS and IBD patients with paired pre- and post-intervention samples using HT U133 Plus PM Array plates (Affymetrix, Santa Clara, CA).
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| Contributor(s) |
Bhasin M, Kuo B, Fricchione GL, Benson H, Libermann TA, Korzenik J, Denninger JW |
| Citation(s) |
25927528 |
| Submission date |
Mar 12, 2015 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Manoj Bhasin |
| Phone |
6176670009
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| Organization name |
Beth Israel Deaconess Medical Center
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| Street address |
330 Brookline Avenue RN 380E
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (66)
|
| GSM1632703 |
Patient A01, IBS, Baseline Before Intervention |
| GSM1632704 |
Patient A01, IBS, After 9 weeks of Intervention |
| GSM1632705 |
Patient A02, IBS, Baseline Before Intervention |
| GSM1632706 |
Patient A02, IBS, After 9 weeks of Intervention |
| GSM1632707 |
Patient A03, IBS, Baseline Before Intervention |
| GSM1632708 |
Patient A03, IBS, After 9 weeks of Intervention |
| GSM1632709 |
Patient A06, IBS, Baseline Before Intervention |
| GSM1632710 |
Patient A06, IBS, After 9 weeks of Intervention |
| GSM1632711 |
Patient A07, IBS, Baseline Before Intervention |
| GSM1632712 |
Patient A07, IBS, After 9 weeks of Intervention |
| GSM1632713 |
Patient A10, IBS, Baseline Before Intervention |
| GSM1632714 |
Patient A10, IBS, After 9 weeks of Intervention |
| GSM1632715 |
Patient A13, IBS, Baseline Before Intervention |
| GSM1632716 |
Patient A13, IBS, After 9 weeks of Intervention |
| GSM1632717 |
Patient A14, IBS, Baseline Before Intervention |
| GSM1632718 |
Patient A14, IBS, After 9 weeks of Intervention |
| GSM1632719 |
Patient A15, IBS, Baseline Before Intervention |
| GSM1632720 |
Patient A15, IBS, After 9 weeks of Intervention |
| GSM1632721 |
Patient A16, IBS, Baseline Before Intervention |
| GSM1632722 |
Patient A16, IBS, After 9 weeks of Intervention |
| GSM1632723 |
Patient A18, IBS, Baseline Before Intervention |
| GSM1632724 |
Patient A18, IBS, After 9 weeks of Intervention |
| GSM1632725 |
Patient A20, IBS, Baseline Before Intervention |
| GSM1632726 |
Patient A20, IBS, After 9 weeks of Intervention |
| GSM1632727 |
Patient A23, IBS, Baseline Before Intervention |
| GSM1632728 |
Patient A23, IBS, After 9 weeks of Intervention |
| GSM1632729 |
Patient A25, IBS, Baseline Before Intervention |
| GSM1632730 |
Patient A25, IBS, After 9 weeks of Intervention |
| GSM1632731 |
Patient B01, IBD, Before Intervention |
| GSM1632732 |
Patient B01, IBD, After 9 weeks of Intervention |
| GSM1632733 |
Patient B03, IBD, Before Intervention |
| GSM1632734 |
Patient B03, IBD, After 9 weeks of Intervention |
| GSM1632735 |
Patient B04, IBD, Before Intervention |
| GSM1632736 |
Patient B04, IBD, After 9 weeks of Intervention |
| GSM1632737 |
Patient B06, IBD, Before Intervention |
| GSM1632738 |
Patient B06, IBD, After 9 weeks of Intervention |
| GSM1632739 |
Patient B07, IBD, Before Intervention |
| GSM1632740 |
Patient B07, IBD, After 9 weeks of Intervention |
| GSM1632741 |
Patient B08, IBD, Before Intervention |
| GSM1632742 |
Patient B08, IBD, After 9 weeks of Intervention |
| GSM1632743 |
Patient B09, IBD, Before Intervention |
| GSM1632744 |
Patient B09, IBD, After 9 weeks of Intervention |
| GSM1632745 |
Patient B11, IBD, Before Intervention |
| GSM1632746 |
Patient B11, IBD, After 9 weeks of Intervention |
| GSM1632747 |
Patient B12, IBD, Before Intervention |
| GSM1632748 |
Patient B12, IBD, After 9 weeks of Intervention |
| GSM1632749 |
Patient B13, IBD, Before Intervention |
| GSM1632750 |
Patient B13, IBD, After 9 weeks of Intervention |
| GSM1632751 |
Patient B14, IBD, Before Intervention |
| GSM1632752 |
Patient B14, IBD, After 9 weeks of Intervention |
| GSM1632753 |
Patient B16, IBD, Before Intervention |
| GSM1632754 |
Patient B16, IBD, After 9 weeks of Intervention |
| GSM1632755 |
Patient B20, IBD, Before Intervention |
| GSM1632756 |
Patient B20, IBD, After 9 weeks of Intervention |
| GSM1632757 |
Patient B22, IBD, Before Intervention |
| GSM1632758 |
Patient B22, IBD, After 9 weeks of Intervention |
| GSM1632759 |
Patient B23, IBD, Before Intervention |
| GSM1632760 |
Patient B23, IBD, After 9 weeks of Intervention |
| GSM1632761 |
Patient B24, IBD, Before Intervention |
| GSM1632762 |
Patient B24, IBD, After 9 weeks of Intervention |
| GSM1632763 |
Patient B25, IBD, Before Intervention |
| GSM1632764 |
Patient B25, IBD, After 9 weeks of Intervention |
| GSM1632765 |
Patient B29, IBD, Before Intervention |
| GSM1632766 |
Patient B29, IBD, After 9 weeks of Intervention |
| GSM1632767 |
Patient B30, IBD, Before Intervention |
| GSM1632768 |
Patient B30, IBD, After 9 weeks of Intervention |
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| Relations |
| BioProject |
PRJNA278043 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE66824_RAW.tar |
164.5 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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