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Series GSE63617 Query DataSets for GSE63617
Status Public on Feb 26, 2015
Title Gene expression profiling of the AD11 anti-NGF transgenic mouse model of neurodegeneration at 1, 3, 6, 15 months of age
Organism Mus musculus
Experiment type Expression profiling by array
Summary We characterized the gene expression profile of brain regions at different stages of the Alzheimer’s like neurodegeneration in the anti-NGF AD11 trangenic mouse model. Total RNA was extracted from hippocampus, cortex and basal forebrain of postnatal day 30 (P30, 1 month), P90 (3 months), P180 (6 months) and at 15 months of age. Expression profiles were studied by Agilent microarray analysis, followed by qRT-PCR validation of significant candidates. Wide changes in gene expression profiles occur already at the presymptomatic stage P30, with the most significantly affected clusters of mRNAs are linked to Inflammation and Immune Response.
 
Overall design AD11 mice were compared to the trangenic VH controls. A total of 60 female AD11 mice and 59 female control VH (5 per group) mice were used for this study: 5 AD11 and 4-5 control VH mice for each time point (1,3,6,15 months of age) and brain area (HP, CTX, BFB).
 
Contributor(s) D'Onofrio M, Arisi I, Brandi R, Di Mambro A, Felsani A, Capsoni S, Cattaneo A
Citation(s) 19604602
Submission date Nov 25, 2014
Last update date Jan 12, 2017
Contact name Ivan Arisi
E-mail(s) i.arisi@ebri.it
Phone +39-06-49255230
Organization name European Brain Research Institute
Department Bioinformatics Facility
Street address viale Regina Elena 295
City Roma
ZIP/Postal code 00161
Country Italy
 
Platforms (2)
GPL7042 Agilent-012694 Whole Mouse Genome G4122A (Probe Name version)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (119)
GSM1553734 1m_bfb_AD11 [NFND_251486812129_S01_GE2-v4_91_1_3]
GSM1553735 1m_bfb_AD11 [NFND_251486812129_S01_GE2-v4_91_1_4]
GSM1553736 1m_bfb_AD11 [NFND_251486812130_S01_GE2-v4_91_1_1]
Relations
BioProject PRJNA268478

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63617_RAW.tar 1.4 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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