|
| Status |
Public on Apr 28, 2015 |
| Title |
Molecular control of myeloid suppressors by death pathways |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The goal of this study was to evaluate the mechanisms distinguishing the different forms of myeloid suppressors in cancer and inflammation, and their indivdual roles in T cell suppression
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| |
|
| Overall design |
We used microarrays to profile the expression profile of myeloid suppressor cells in mouse and human samples. The starting point is the attached arrays which use different CD11+ or CD14+ selections to crudely separate the myeloid suppressors from other immune cells. The overall study is an initial step towards much higher resolution genetics studies to determine the functional prathways used by myeloid suppressors to inhibit T-cells.
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| |
|
| Contributor(s) |
Haverkamp J, Neale G, Murray P |
| Citation(s) |
25500368 |
| Submission date |
Sep 17, 2014 |
| Last update date |
Aug 06, 2018 |
| Contact name |
Geoffrey Neale |
| E-mail(s) |
geoffrey.neale@stjude.org
|
| Organization name |
St Jude Childrens Research Hospital
|
| Department |
Hartwell Center
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL11180 |
[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
|
| Samples (12)
|
| GSM1505888 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 1 |
| GSM1505889 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 2 |
| GSM1505890 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 3 |
| GSM1505891 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 4 |
| GSM1505892 |
Spleen Cd11b+ Gr1-low myeloid suppressors from tumor bearing mice Replicate 1 |
| GSM1505893 |
Spleen Cd11b+ Gr1-low myeloid suppressors from tumor bearing mice Replicate 2 |
| GSM1505894 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 5 |
| GSM1505895 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 6 |
| GSM1505896 |
Bone marrow derived Cd11b+ myeloid suppressors Replicate 7 |
| GSM1505897 |
Human CD14+ HLA-DR-/low isolated from peripheral blood Replicate 1 |
| GSM1505898 |
Human CD14+ HLA-DR-/low isolated from peripheral blood Replicate 2 |
| GSM1505899 |
Human CD14+ HLA-DR-/low isolated from peripheral blood Replicate 3 |
|
| Relations |
| BioProject |
PRJNA261278 |
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