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| Status |
Public on Mar 26, 2015 |
| Title |
Genome-wide analysis of bone marrow-derived macrophage (BMDM) priming by Ifng and Ifnb. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Macrophages are a heterogeneous population of immune cells, which are critical for both the initiation and resolution of inflammation. Pro-inflammatory macrophages can be induced by the Th1 cytokine IFNγ and/or TLR triggers, like LPS. Here, we investigated the effects of IFNγ priming on LPS-induced gene expression in primary mouse macrophages.
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| Overall design |
To investigate the effect of IFNγ priming on LPS-induced gene expression in macrophages, we stimulated bone marrow-derived macrophages with IFNγ or IFNb for 18 hours and subsequently activated them with LPS for 6 hours.
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| Contributor(s) |
Scicluna BP, Hoeksma M |
| Citation(s) |
25750432 |
| Submission date |
Aug 11, 2014 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Brendon Scicluna |
| E-mail(s) |
brendon.scicluna@um.edu.mt
|
| Organization name |
University of Malta
|
| Street address |
Msida campus
|
| City |
Msida |
| ZIP/Postal code |
MSD2020 |
| Country |
Malta |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA257967 |
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