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| Status |
Public on Feb 23, 2015 |
| Title |
Methylation data of pediatric B-cell acute leukemias |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles.
The current study identified a link between DNA methylome of B-cell acute lymphoblastic leukemias (B-ALLs) and embryonic stem cell (ESC) bivalency, through which tumor cells can mimic the pluripotency of ESCs.
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| Overall design |
A total of 231 pediatric patients with B-ALL were utilized from the California Childhood Cancer Study. After informed consent, bone marrow specimens packed with leukemic blasts were obtained in each patient. Expression and methylation data of purified Pre-B cells in four developmental stages were retrieved from our previous study (Lee et al., Nucleic Acids Res 2012).
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| Contributor(s) |
Lee S, Wiemels JL |
| Citation(s) |
25690899 |
| Submission date |
Apr 08, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Seung-Tae Lee |
| E-mail(s) |
essere.lee@gmail.com
|
| Phone |
+82-10-9933-5465
|
| Organization name |
UCSF
|
| Street address |
1450 3rd Street
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (227)
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| This SubSeries is part of SuperSeries: |
| GSE56602 |
Two-Track Epigenetic Remodeling and Backtracking to Embryonic Stem Cell Bivalency in B-cell Acute Lymphoblastic Leukemias |
|
| Relations |
| BioProject |
PRJNA244063 |
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