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| Status |
Public on Apr 04, 2014 |
| Title |
Modulation of gene expression induced by supercritical fluid rosemary extract in colon cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Supercritical rosemary extract (containing 16.90% carnosic acid, 1.90% carnosol and 13.59% volatile compounds) showed antitumor activity on colon cancer cells in vitro. We treated colon cancer cells with the extract and we employed whole genome microarray expression profiling to identify genes potentially involved in its antitumor mechanism of action.
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| Overall design |
We analyzed gene expression of colon cancer SW620 cells after treating during 48h with supercritical rosemary extract at concentrations that cause 50% inhibition of cell viability (30 μg/mL), citostatic effect (60 μg/mL) and 50% cell death (100 μg/mL), in comparison to control cells (0 μg/mL). Two independent experiments were performed in triplicate. Each sample is the pool of the triplicates of one of the experiments (a or b) at the indicated concentration.
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| Contributor(s) |
Ramírez de Molina A, González-Vallinas M, Martín-Hernández R, Molina S |
| Citation(s) |
24892299 |
| Submission date |
Apr 03, 2014 |
| Last update date |
Jan 23, 2019 |
| Contact name |
ROBERTO MARTIN-HERNANDEZ |
| Organization name |
IMDEA ALIMENTACION
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| Department |
BIOSTATISTICS AND BIOINFORMATICS UNIT
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| Street address |
CANTOBLANCO
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| City |
MADRID |
| ZIP/Postal code |
28049 |
| Country |
Spain |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA243520 |
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