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| Status |
Public on Feb 24, 2014 |
| Title |
Obesity-associated variants within FTO form long-range functional connections with IRX3 |
| Organisms |
Danio rerio; Mus musculus |
| Experiment type |
Other
|
| Summary |
Genome-wide association studies in diverse populations have reproducibly associated variants within introns of FTO with increased risk for obesity and type-2 diabetes.While the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice demonstrated that FTO expression levels influence body mass and composition phenotypes. Yet, no direct connection between the obesity-associated intronic variants and FTO expression or function has been made. We show that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, primarily with the homeobox gene IRX3, rather than with FTO.
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| Overall design |
4C-seq samples for Fto/fto and Irx3/irx3a genes promoters in different samples: adult mouse brain, E9.5 mouse embryos and 24hpf zebrafish embryos.
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| Contributor(s) |
Smemo S, Tena JJ, Naranjo S, Domínguez-Acemel R, Gómez-Skarmeta JL, Nobrega MA |
| Citation(s) |
24646999 |
| Submission date |
Nov 29, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Juan J. Tena |
| E-mail(s) |
jjtenagu@upo.es
|
| Organization name |
CABD/CSIC
|
| Street address |
Univ. Pablo Olavide, Ctra. Utrera km1
|
| City |
Sevilla |
| ZIP/Postal code |
41013 |
| Country |
Spain |
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| Platforms (2) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL14875 |
Illumina HiSeq 2000 (Danio rerio) |
|
| Samples (6)
|
| GSM1276793 |
4C-Seq for FTO promoter in E9.5 mouse_embryos |
| GSM1276794 |
4C-Seq for Irx3 promoter in E9.5 mouse_embryos |
| GSM1276795 |
4C-Seq for FTO promoter in mouse adult brain |
| GSM1276796 |
4C-Seq for Irx3 promoter in mouse adult brain |
| GSM1276797 |
4C-Seq for FTO promoter in 24hpf zebrafish |
| GSM1276798 |
4C-Seq for Irx3a promoter in 24hpf zebrafish |
|
| Relations |
| BioProject |
PRJNA230260 |
| SRA |
SRP033390 |
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