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| Status |
Public on May 14, 2014 |
| Title |
Guselkumab (interleukin-23-specific monoclonal antibody) demonstrates clinical and molecular response in moderate-to-severe psoriasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A gene expression profiling study was conducted in which skin biopsy samples were collected for RNA extraction and hybridization to microarrays from patients with moderate-to-severe psoriasis who participated in the phase 1, guselkumab first-in-human randomized, double-blind, placebo-controlled trial.
At week 12, significant reductions in psoriasis gene expression were observed in guselkumab-treated patients.
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| Overall design |
Skin biopsy samples (n=59, LS: lesion, NL: non-lesion) were collected at baseline, weeks 1 and 12 following guselkumab treatment from patients with moderate-to-severe psoriasis for RNA extraction and microarray analysis.
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| Contributor(s) |
Sofen H, Smith S, Matheson RT, Leonardi CL, Calderon C, Brodmerkel C, Li K, Campbell K, Marciniak SJ Jr, Wasfi Y, Wang Y, Szapary P, Krueger JG |
| Citation(s) |
24679469, 37071038 |
| Submission date |
Oct 18, 2013 |
| Last update date |
Nov 09, 2023 |
| Contact name |
K Li |
| E-mail(s) |
kli@its.jnj.com
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| Organization name |
Janssen R&D
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| Street address |
1400 McKean Road
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| City |
Spring House |
| State/province |
PA |
| ZIP/Postal code |
19477 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (59)
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| Relations |
| BioProject |
PRJNA223228 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE51440_RAW.tar |
117.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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