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Series GSE51068 Query DataSets for GSE51068
Status Public on Sep 25, 2014
Title High-throughput expression profiling of OCI-Ly3 cell line upon treatment with a panel of 14 known drugs.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Analysis of Diffuse Large B-Cell Lymphoma (DLBCL) OCI-LY3 cell line treated with 14 different known drugs at 2 different concentrations and profiled at 6, 12 and 24 hrs after treatment.
We used this gene expression data to design a challenge where participants were required to develop methods to predict activity of compound pairs using gene expression profile following single compound treatment, drug response curve of each compound and baseline genetic profile of OCI-LY3 cell line.
 
Overall design GeneChip HT HG-U219 array plates were used to analyze gene expression changes induced by treatment with 14 drug compounds in OCI-Ly3 cells at 6, 12 and 24h. 3 replicates were analyxed for each drug/time combination. Vehicle (DMSO)-treated control samples were used for comparison with each replicate. Altogether 282 samples were analyzed in this study.
 
Contributor(s) Mattioli M, Karan C, Bansal M, Califano A, Stolovitzky G
Citation(s) 25419740
Submission date Sep 20, 2013
Last update date Mar 21, 2019
Contact name Mukesh Bansal
Organization name Columbia University
Street address 1130 St. Nicholas Ave. Room 908
City New York
State/province NY
ZIP/Postal code 10032
Country USA
 
Platforms (1)
GPL13667 [HG-U219] Affymetrix Human Genome U219 Array
Samples (282)
GSM1237021 A01 OCI-LY3 cell line, Methotrexate, 100 uM, 6hrs, Replicate1
GSM1237022 A02 OCI-LY3 cell line, Methotrexate, 100 uM, 6hrs, Replicate2
GSM1237023 A03 OCI-LY3 cell line, Methotrexate, 100 uM, 6hrs, Replicate3
Relations
BioProject PRJNA220987

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51068_RAW.tar 610.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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