|
| Status |
Public on Jan 12, 2013 |
| Title |
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development (aCGH) |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Prostate cancer research is hampered by a lack of preclinical models which accurately reproduce clinical heterogeneity. We have established a bank of transplantable patient-derived prostate tumor xenograft lines, using subrenal capsule grafting of human tumor tissue into immuno-deficient mice. This panel includes the first lines generated from prostate cancer biopsy tissue, and also new lines from metastatic tissue. The lines retained salient features of the original patient tumors, including histopathological and molecular characteristics. Furthermore, they span major subtypes of prostate cancer, capturing diverse inter- and intra-tumoral heterogeneity. Host castration led to the development of castrate-resistant tumors, including the first model of neuroendocrine transdifferentiation. This publicly-available resource provides novel tools for the next-generation of prostate cancer research and therapy development.
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| |
|
| Overall design |
3 primary tumors and 21 xenograft tumors
|
| |
|
| Contributor(s) |
Lin D, Wyatt AW, Brahmbhatt S, Haegert A, Anderson SA |
| Citation(s) |
25544761, 25859291, 24589457 |
| Submission date |
Sep 27, 2012 |
| Last update date |
Oct 22, 2019 |
| Contact name |
Shawn Anderson |
| E-mail(s) |
Sanderson@prostatecentre.com
|
| Organization name |
Vancouver Prostate Centre
|
| Lab |
Laboratory for Advanced Genome Analysis
|
| Street address |
2660 Oak Street
|
| City |
Vancouver |
| State/province |
BC |
| ZIP/Postal code |
V6H3Z6 |
| Country |
Canada |
| |
|
| Platforms (2) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
| GPL10152 |
Agilent-021924 SurePrint G3 Human CGH Microarray 8x60K (Feature Number version) |
|
| Samples (24)
|
|
| This SubSeries is part of SuperSeries: |
| GSE41193 |
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development |
|
| Relations |
| BioProject |
PRJNA176140 |
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