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Series GSE40744 Query DataSets for GSE40744
Status Public on Feb 20, 2013
Title Identification of microRNAs specifically expressed in HCV-associated hepatocellular carcinoma
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Background: Several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC) but the data are not univocal.

Methods: We performed a microarray study of miRNAs in hepatitis C virus (HCV)-associated HCC and other liver diseases and healthy conditions.

Results and Conclusions: The simultaneous comparison of different liver diseases and normal livers allowed the identification of 18 miRNAs exclusively expressed in HCV-associated HCC, with sensitivity and specificity values of diagnostic-grade.
 
Overall design A total number of 76 liver specimens obtained from 43 patients were analyzed: 26 liver specimens obtained from 10 patients with HCV-associated HCC, including 9 specimens from the tumor area (HCC) and 17 specimens from the surrounding non-tumorous tissue affected by cirrhosis (HCC-CIR); 18 specimens from 10 patients with HCV-associated cirrhosis without HCC (CIR); 13 specimens from 4 patients with HBV-associated acute liver failure (ALF); 12 specimens from 12 liver donors (LD); and 7 from normal liver of 7 subjects who underwent hepatic resection for liver angioma (NL).
 
Contributor(s) Diaz G, Melis M, Tice A, Kleiner DE, Mishra L, Zamboni F, Farci P
Citation(s) 23390000
Submission date Sep 10, 2012
Last update date May 02, 2017
Contact name Patrizia Farci
E-mail(s) pfarci@niaid.nih.gov
Phone 301-5942325
Organization name National Institutes of Health
Department National Institute of Allergy and Infectious Diseases
Lab Hepatic Pathogenesis Section-Laboratory of Infectious Diseases
Street address 50 South Drive
City Bethesda
State/province MD
ZIP/Postal code 20892-8009
Country USA
 
Platforms (1)
GPL14613 [miRNA-2] Affymetrix Multispecies miRNA-2 Array
Samples (76)
GSM1000469 Normal liver - patient 1 - specimen 1
GSM1000470 Normal liver - patient 2 - specimen 1
GSM1000471 Normal liver - patient 3 - specimen 1
Relations
BioProject PRJNA174797

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40744_RAW.tar 50.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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