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| Status |
Public on Dec 30, 2011 |
| Title |
Expression data from Ad-β-catenin-GFP or Ad-GFP infected cardiomyocytes |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
The Wnt pathway is a key regulator of embryonic development, cell growth, differentiation, polarity formation, neural development, carcinogenesis, and stem cell self-renewal, and deregulation of the Wnt signalling is associated with many human disease. The central player in the Wnt pathway is β-catenin, A recent study has shown that β-catenin/Tcf/Lef signaling pathway is an essential growth-regulatory pathway in cardiomyocytes.
We used DNA microarrays to detail the global trends in gene expression underlying β-catenin-overexpressed cardiomyocytes and identified distinct classes of up- or down-regulated genes during this process. Our findings suggest that β-catenin plays a critical role in regulating cardiac dysfunction at transcriptional level and may provide novel insight into how β-catenin modulates heart diseases.
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| Overall design |
Cardiomyocytes were infected with GFP control or β-catenin adenoviruses for RNA extraction and hybridization on Affymetrix microarrays. We sought to define the effects of β-catenin on the global programme of gene expression in primary cardiomyocytes. To that end, neonatal rat cardiomyocytes were infected with GFP control (G) or β-catenin adenovirus (B) for 24 hours.
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| Contributor(s) |
Li JJ, Li HH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 29, 2011 |
| Last update date |
Jul 31, 2017 |
| Contact name |
junjie li |
| Organization name |
PUMC
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| Street address |
#5 Dong Dan San Tiao
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| City |
Beijing |
| ZIP/Postal code |
100005 |
| Country |
China |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (4)
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| GSM854976 |
Cardiomyocytes-Ad-GFP, biological rep1 |
| GSM854977 |
Cardiomyocytes-Ad-GFP, biological rep2 |
| GSM854978 |
Cardiomyocytes-Ad-β-catenin-GFP, biological rep1 |
| GSM854979 |
Cardiomyocytes-Ad-β-catenin-GFP, biological rep2 |
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| Relations |
| BioProject |
PRJNA150345 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE34772_Bcluster.txt.gz |
13.7 Kb |
(ftp)(http) |
TXT |
| GSE34772_RAW.tar |
10.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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