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| Status |
Public on Jul 11, 2011 |
| Title |
Expression Profiling of Mixed Lineage Leukemia Cells Treated with a Potent Small-Molecule DOT1L Inhibitor |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cell lines bearing MLL translocations (MV4-11 and MOLM-13) were treated with a potent, selective inhibitor of the DOT1L histone methyl transferase. Treatment of MLL-rearranged cell lines with the DOT1L inhibitor selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Here we provide expression profiling data of cells treated with DOT1L inhibitor or vehicle control.
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| Overall design |
MV4-11 cells were treated with 3 uM EPZ004777 (DOT1L inhibitor) or vehicle control (0.1% DMSO) for 2, 4 and 6 days. MOLM-13 cells were treated with 3 uM EPZ004777 (DOT1L inhibitor) or vehicle control (0.1% DMSO) for 6 days. For each unique conditon, 3 biological replicates were generated for expression profiling.
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| Contributor(s) |
Daigle SR, Smith JJ, Pollock RM |
| Citation(s) |
21741596 |
| Submission date |
Jun 08, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jesse Jerome Smith |
| E-mail(s) |
jsmith@epizyme.com
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| Phone |
617-500-0596
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| URL |
http://www.epizyme.com
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| Organization name |
Epizyme
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| Department |
Biological Sciences
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| Street address |
325 Vassar Street, Suite 2B
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (24)
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| GSM739148 |
3 uM EPZ004777 treated, DAY 2, biological rep.1, MV4-11 cells |
| GSM739149 |
3 uM EPZ004777 treated, DAY 2, biological rep.2, MV4-11 cells |
| GSM739150 |
3 uM EPZ004777 treated, DAY 2, biological rep.3, MV4-11 cells |
| GSM739151 |
Vehicle treated, DAY 2, biological rep.1, MV4-11 cells |
| GSM739152 |
Vehicle treated, DAY 2, biological rep.2, MV4-11 cells |
| GSM739153 |
Vehicle treated, DAY 2, biological rep.3, MV4-11 cells |
| GSM739154 |
3 uM EPZ004777 treated, DAY 4, biological rep.1, MV4-11 cells |
| GSM739155 |
3 uM EPZ004777 treated, DAY 4, biological rep.2, MV4-11 cells |
| GSM739156 |
3 uM EPZ004777 treated, DAY 4, biological rep.3, MV4-11 cells |
| GSM739157 |
Vehicle treated, DAY 4, biological rep.1, MV4-11 cells |
| GSM739158 |
Vehicle treated, DAY 4, biological rep.2, MV4-11 cells |
| GSM739159 |
Vehicle treated, DAY 4, biological rep.3, MV4-11 cells |
| GSM739160 |
3 uM EPZ004777 treated, DAY 6, biological rep.1, MV4-11 cells |
| GSM739161 |
3 uM EPZ004777 treated, DAY 6, biological rep.2, MV4-11 cells |
| GSM739162 |
3 uM EPZ004777 treated, DAY 6, biological rep.3, MV4-11 cells |
| GSM739163 |
Vehicle treated, DAY 6, biological rep.1, MV4-11 cells |
| GSM739164 |
Vehicle treated, DAY 6, biological rep.2, MV4-11 cells |
| GSM739165 |
Vehicle treated, DAY 6, biological rep.3, MV4-11 cells |
| GSM739166 |
3 uM EPZ004777 treated, DAY 6, biological rep.1, MOLM-13 cells |
| GSM739167 |
3 uM EPZ004777 treated, DAY 6, biological rep.2, MOLM-13 cells |
| GSM739168 |
3 uM EPZ004777 treated, DAY 6, biological rep.3, MOLM-13 cells |
| GSM739169 |
Vehicle treated, DAY 6, biological rep.1, MOLM-13 cells |
| GSM739170 |
Vehicle treated, DAY 6, biological rep.2, MOLM-13 cells |
| GSM739171 |
Vehicle treated, DAY 6, biological rep.3, MOLM-13 cells |
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| Relations |
| BioProject |
PRJNA140999 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29828_RAW.tar |
116.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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