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| Status |
Public on May 13, 2012 |
| Title |
C/EBPa Regulates Protease/anti-protease Balance and Mediates Bronchiolar Cell Recovery After Injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In the present study, we hypothesized that C/EBPa (CCAAT/enhancer-binding protein alpha) plays a role in cell regeneration in response to bronchiolar epithelial cell injury. C/EBPa mediated ciliated cell regeneration after naphthalene bronchiolar epithelial cell injury in vivo. Furthermore, we demonstrated that C/EBPa regulates protease/anti-protease balance after lung injury, and intratracheal treatment with anti-protease (BPTI) restored ciliated cell regeneration after naphthalene injury in CebpaD/D mice.
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| |
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| Overall design |
Cebpa d/d VS. Control mice 0hr, 3hr and 72hr after naphthalene injury. Three replicates each.
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| |
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| Contributor(s) |
Sato A, Xu Y, Whitsett JA, Ikegami M |
| Citation(s) |
22652201 |
| Submission date |
May 13, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Yan Xu |
| E-mail(s) |
yan.xu@cchmc.org
|
| Phone |
513-6368921
|
| Organization name |
Cincinnati Children's Hospital Medical Center
|
| Street address |
3333 Burnet Ave
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (18)
|
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| Relations |
| BioProject |
PRJNA141613 |
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