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| Status |
Public on Apr 01, 2012 |
| Title |
Expression data from the mouse liver with constitutively active NF-kB |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Activation of hepatic NF-kB signaling induces inflammation and ultimately fibrosis.
To investigate the underlying mechanism, we used microarrays to detail the global programme of gene expression which is regulated by hepatic NF-kB signaling.
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| Overall design |
We generated transgenic mice which express a constitutively active IKK2 controlled under the LAP promotor. The liver samples were collected from transgenic mice as well as from control animals at the age of 4 weeks. RNA extraction was performed from these liver samples and hybridized on Affymetrix microarrays.
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| Contributor(s) |
Sunami Y, Strnad P, Holzmann K, Wirth T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 22, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Karlheinz Holzmann |
| E-mail(s) |
karlheinz.holzmann@uni-ulm.de
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| Organization name |
Ulm University
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| Department |
Medical Faculty
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| Lab |
Genomics Core Facility
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| Street address |
Helmholtzstreet 8/1
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| City |
Ulm |
| ZIP/Postal code |
D-89081 |
| Country |
Germany |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM694322 |
Mouse liver, constitutively active IKK2, biological replicate 1 |
| GSM694323 |
Mouse liver, constitutively active IKK2, biological replicate 2 |
| GSM694324 |
Mouse liver, constitutively active IKK2, biological replicate 3 |
| GSM694325 |
Mouse liver, constitutively active IKK2, biological replicate 4 |
| GSM694326 |
Mouse liver, cotrol animal, biological replicate 1 |
| GSM694327 |
Mouse liver, cotrol animal, biological replicate 2 |
| GSM694328 |
Mouse liver, cotrol animal, biological replicate 3 |
| GSM694329 |
Mouse liver, cotrol animal, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA139735 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28085_RAW.tar |
30.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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