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Series GSE27040 Query DataSets for GSE27040
Status Public on May 03, 2012
Title Dermatan sulfate is involved in the tumorigenic properties of Esophagus Squamous Cell Carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. The main IdoA-producing enzyme, DS epimerase 1 (DS-epi1) was highly up-regulated in ESCC biopsies. To further understand the roles of IdoA in tumor development, DS-epi1 expression, and consequently IdoA content, was downregulated in ESCC cells. IdoA-deficient cells exhibited decreased migration and invasion capabilities in vitro, which was associated with reduced cellular binding of hepatocyte growth factor, inhibition of pERK-1/2 signaling, and de-regulated actin cytoskeleton dynamics and focal adhesion formation. Our findings demonstrate that IdoA in DS influences tumorigenesis by affecting cancer cell behavior.
 
Overall design Gene expression data including 10 Esophageal squamous carcinoma specimens and 27 gastroesophageal adenocarcinoma specimens.
 
Citation(s) 22350411
Submission date Feb 03, 2011
Last update date May 03, 2012
Contact name Anna Isinger Ekstrand
E-mail(s) anna.ekstrand@med.lu.se
Organization name Clinical Sciences
Department Oncology
Street address Barngatan 2b
City Lund
ZIP/Postal code 221 85
Country Sweden
 
Platforms (2)
GPL5886 SWEGENE H_v2.1.1_27k
GPL10468 Swegene H_v2.1.1_20k
Samples (39)
GSM548235 Distal esophageal adenocarcinoma 104
GSM548236 Proximal stomach adenocarcinoma 107
GSM548237 Proximal stomach adenocarcinoma 110
Relations
BioProject PRJNA137669

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27040_RAW.tar 120.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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