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| Status |
Public on May 16, 2024 |
| Title |
Clinical and molecular characterization of the cisplatin-vinorelbine chemotherapeutic regimen in HER2(-) metastatic breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Despite rapid advances in treatment options, challenges still persist in advanced breast cancer. Bevacizumab is a VEGF-neutralizing antibody with proven efficacy in combination with chemotherapy for treatment of HER2 negative metastatic breast cancer (mBC). Vinorelbine, a semisynthetic vinca alkaloid, is a well-established and well tolerated chemotherapeutic in breast cancer. The combination of vinorelbine with platinum and addition of bevacizumab is relatively underreported in the literature. We propose this combination regimen as safe, well tolerated and efficacious in HER2 negative mBC patients.
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| Overall design |
To model the molecular perturbations by cisplatin-vinorelbine combination, we treated the triple negative breast cancer MDA-MB-231 cell line with a combination of 7μM cisplatin + 14μM vinorelbine, in comparison to vehicle treatment. Total RNA extracted from treated cells underwent RNA-sequencing for transcriptional profiling.
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| Contributor(s) |
Ho I, Tseng Y, Liu C, Tsai Y, Huang C, Tseng L, Chao T, Lai J |
| Citation missing |
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| BioProject |
PRJNA1108178 |
| Submission date |
May 15, 2024 |
| Last update date |
May 16, 2024 |
| Contact name |
Jiun-I Lai |
| E-mail(s) |
lji0428@gmail.com
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| Organization name |
National Yang-Ming Chiao-Tung University
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| Department |
Institute of Clinical Medicine
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| Street address |
no 155, linong street
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| City |
taipei |
| State/province |
State... |
| ZIP/Postal code |
106 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| GSM8270968 |
MDA-MB-231 treated with DMSO repeat 1 |
| GSM8270969 |
MDA-MB-231 treated with DMSO repeat 2 |
| GSM8270970 |
MDA-MB-231 treated with cisplatin/vinorelbine repeat 1 |
| GSM8270971 |
MDA-MB-231 treated with cisplatin/vinorelbine repeat 2 |
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