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| Status |
Public on Jan 17, 2024 |
| Title |
Gene Expression Profiles Induced by RNA interference on NSD1 Δ5Δ7, and NSD1 Δ19–23 isoforms in Fibroblast Cells I. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
NSD1 Δ5Δ7, NSD1 Δ19–23 5’end and canonical NSD1 transcript are involved in cell cycle regulation and in tumoral and neoplastic development. Another NSD1 isoform AT2 target that might mediate the cellular division mechanisms is ARP3 actin-related protein 3 homolog B ACTR3B that may act downstream of the stress fibers and bundle of actin filaments formation
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| Overall design |
Fibroblasts cell obtained from four different healthy donors were screened to confirm the absence of NSD1 mutation
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| Contributor(s) |
Conteduca G, Cangelosi D, Malacarne M, Baldo C, Arado A, Testa B, Wagner RT, Robertson KD, Dequiebedt F, Filaci G, Coviello DA |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 16, 2024 |
| Last update date |
Jan 17, 2024 |
| Contact name |
Giuseppina Conteduca |
| E-mail(s) |
giusy_conteduca@alice.it
|
| Organization name |
IRCCS Ospedale San Martino
|
| Lab |
U.O bioterapie
|
| Street address |
Largo Rosanna Benzi 10
|
| City |
Genova |
| State/province |
GE |
| ZIP/Postal code |
16132 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
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| Samples (8)
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| GSM8020118 |
Dataset 1 Fibroblasts Dataset 1 From control wild type1 |
| GSM8020119 |
Dataset 1 Fibroblasts Dataset 1 From control wild type2 |
| GSM8020120 |
Dataset 1 Fibroblasts treated 1 |
| GSM8020121 |
Dataset 1 Fibroblasts treated 2 |
| GSM8020122 |
Dataset 1 Fibroblasts Dataset 1 From control wild type3 |
| GSM8020123 |
Dataset 1 Fibroblasts Dataset 1 From control wild type4 |
| GSM8020124 |
Dataset 1 Fibroblasts treated 3 |
| GSM8020125 |
Dataset 1 Fibroblasts treated 4 |
|
| Relations |
| BioProject |
PRJNA1065461 |
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