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| Status |
Public on Jun 27, 2011 |
| Title |
Pneumococcal conjugate vaccination at birth induces robust recall responses at 9 months of age. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The objective of this study was to compare recall responses to vaccine antigens at 3 months and 9 months of age in infants who were vaccinated at birth or at 1 month.
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| Overall design |
PBMC were obtained at 9 months of age from infants who were vaccinated at birth (n=25) or 1 month (n=25). The PBMC were cultured in the presence or absence of CRM197 antigen for 72 hours. At the termination of the cultures, total RNA was extracted from the PBMC. The RNA was pooled into groups of n=5 subjects per group, following by labeling and hybridization to Affymetrix microarrays.
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| Contributor(s) |
van den Biggelaar AH, Pomat W, Bosco A, Phuanukoonnon S, Devitt CJ, Nadal-Sims MA, Siba PM, Richmond PC, Lehmann D, Holt PG |
| Citation(s) |
21645573 |
| Submission date |
Nov 10, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Anthony Bosco |
| E-mail(s) |
Anthony.Bosco@telethonkids.org.au
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| Organization name |
Telethon Kids Institute
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| Street address |
100 Roberts Road
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| City |
Subiaco |
| State/province |
WA |
| ZIP/Postal code |
6008 |
| Country |
Australia |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (20)
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| GSM621609 |
Unstimulated PBMC from vaccinated infants, RNA pool/group 1 |
| GSM621610 |
CRM-stimulated PBMC from vaccinated infants, RNA pool/group 1 |
| GSM621611 |
Unstimulated PBMC from vaccinated infants, RNA pool/group 2 |
| GSM621612 |
CRM-stimulated PBMC from vaccinated infants, RNA pool/group 2 |
| GSM621613 |
Unstimulated PBMC from vaccinated infants, RNA pool/group 3 |
| GSM621614 |
CRM-stimulated PBMC from vaccinated infants, RNA pool/group 3 |
| GSM621615 |
Unstimulated PBMC from vaccinated infants, RNA pool/group 4 |
| GSM621616 |
CRM-stimulated PBMC from vaccinated infants, RNA pool/group 4 |
| GSM621617 |
Unstimulated PBMC from vaccinated infants, RNA pool/group 5 |
| GSM621618 |
CRM-stimulated PBMC from vaccinated infants, RNA pool/group 5 |
| GSM621619 |
Unstimulated PBMC from vaccinated newborns, RNA pool/group 1 |
| GSM621620 |
CRM-stimulated PBMC from vaccinated newborns, RNA pool/group 1 |
| GSM621621 |
Unstimulated PBMC from vaccinated newborns, RNA pool/group 2 |
| GSM621622 |
CRM-stimulated PBMC from vaccinated newborns, RNA pool/group 2 |
| GSM621623 |
Unstimulated PBMC from vaccinated newborns, RNA pool/group 3 |
| GSM621624 |
CRM-stimulated PBMC from vaccinated newborns, RNA pool/group 3 |
| GSM621625 |
Unstimulated PBMC from vaccinated newborns, RNA pool/group 4 |
| GSM621626 |
CRM-stimulated PBMC from vaccinated newborns, RNA pool/group 4 |
| GSM621627 |
Unstimulated PBMC from vaccinated newborns, RNA pool/group 5 |
| GSM621628 |
CRM-stimulated PBMC from vaccinated newborns, RNA pool/group 5 |
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| Relations |
| BioProject |
PRJNA134803 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE25263_RAW.tar |
85.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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