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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 03, 2011 |
| Title |
Expression data from mouse ovarian surface epithelium cells at different stages of malignancy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Ovarian cancer is one of the most deadly cancers accounting for only 3% of diagnosed cancers, but is the fifth leading cause of cancer deaths among woman; however, the progression of ovarian cancer is poorly understood. To study and further understand the early events that lead to epithelial derived ovarian cancer, we previously developed a cell model of progressive ovarian cancer. Mouse ovarian surface epithelial (MOSE) cells have undergone spontaneous transformation in cell culture and represent pre-neoplastic, non-tumorigenic to an aggressive malignant phenotype.
Microarray analysis was performed with RNA isolated from different stages of MOSE cells to examine changes in gene expression as MOSE cells transition from a pre-neoplastic to a malignant state.
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| Overall design |
RNA was isolated from MOSE early cell representing a pre-neoplastic, non-malignant stage, MOSE Intermediate cells representing a noeplastic, pre-invasive state, and MOSE Late cells representing a malignant, invasive stage. Three biological replicates were used to take into account variations within the heterogeneous cultures.
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| Contributor(s) |
Creekmore AL, Schmelz EM |
| Citation(s) |
21390237 |
| Submission date |
Oct 19, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Eva M Schmelz |
| E-mail(s) |
eschmelz@vt.edu
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| Organization name |
Virginia Tech
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| Department |
HNFE
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| Lab |
Schmelz
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| Street address |
Virginia Tech
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| City |
Blacksburg |
| State/province |
VA |
| ZIP/Postal code |
24060 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (9)
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| GSM610470 |
MOSE Early Cells, biological replicate 1 |
| GSM610471 |
MOSE Early Cells, biological replicate 2 |
| GSM610472 |
MOSE Early Cells, biological replicate 3 |
| GSM610473 |
MOSE Intermediate Cells, biological replicate 1 |
| GSM610474 |
MOSE Intermediate Cells, biological replicate 2 |
| GSM610475 |
MOSE Intermediate Cells, biological replicate 3 |
| GSM610476 |
MOSE Late Cells, biological replicate 1 |
| GSM610477 |
MOSE Late Cells, biological replicate 2 |
| GSM610478 |
MOSE Late Cells, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA132243 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24789_RAW.tar |
33.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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