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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 06, 2024 |
| Title |
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection: a translational study [scRNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
S100A8 and S100A9 (aliases MRP8 and MRP14) are highly expressed in neutrophils and monocytes and are classified as damage-associated molecular pattern (DAMP) molecules or alarm molecules. However, the role of S100A8/A9 in aortic dissection has not been reported. In the present study, by employing an unbiased proteomics approach and RNA sequencing analysis , we found that the protein expression of calcium binding proteins S100A8/A9 were upregulated in the aorta and serum of TAAAD patients and also in a mouse model.
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| Overall design |
We performed a single-cell RNA sequencing analysis of aorta samples from mice AD model. AD model was established as follows: three-week-old male mice were conventionally fed normal chow and given BAPN (A3134, Sigma-Aldrich, St. Louis, Missouri, USA) in drinking water (1 g/kg/d)) for 4 consecutive weeks, and Paquinimod (ABR 25757, T7310, Targetmol, Shanghai, China) (10 mg/kg/d) was given via intragastric administration until experimental termination.
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| Contributor(s) |
Jiang H, Xu S, Ge J |
| Citation(s) |
38056513 |
| Submission date |
Nov 07, 2023 |
| Last update date |
May 07, 2024 |
| Contact name |
Hui Jiang |
| E-mail(s) |
ahjianghui@mail.ustc.edu.cn
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| Phone |
13637057250
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| Organization name |
University of Science and Technology of China
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| Street address |
96 Jinzhai Road
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| City |
Hefei |
| State/province |
AnHui |
| ZIP/Postal code |
230000 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1036729 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE247260_RAW.tar |
397.5 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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