|
| Status |
Public on May 10, 2024 |
| Title |
Relaxin Attenuates the Genomic Actions and Biological Effects of Estrogens in the Myometrium by Reducing Estrogen Receptor Alpha Phosphorylation [ChIP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In this study we examine the extent and nature of functional interactions between the E2 and Rln signaling pathways in the myometrium. In addition, we delineate the mechanisms underlying functional interplay between the E2/ERĪ± and Rln/RXFP1 signaling pathways at the molecular and physiological levels in myometrial tissue and cells during quiescence and contractility.
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| |
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| Overall design |
ChIP-seq was performed on purified ChIPed DNA obtained from ovariectomized mouse myometrium. Immunoprecipitation was performed using the polyclonal antibodies for ERa, H3K27ac, or H3K4me1.
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| |
|
| Contributor(s) |
Tripathy S, Nagari A, Mahendroo M, Kraus WL |
| Citation(s) |
38659934 |
| Submission date |
Oct 06, 2023 |
| Last update date |
May 10, 2024 |
| Contact name |
W. Lee Kraus |
| E-mail(s) |
lee.kraus@utsouthwestern.edu
|
| Organization name |
UT Southwestern Medical Center
|
| Street address |
5323 Harry Hines Blvd.
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390-8511 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (32)
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| This SubSeries is part of SuperSeries: |
| GSE244843 |
Relaxin Attenuates the Genomic Actions and Biological Effects of Estrogens in the Myometrium by Reducing Estrogen Receptor Alpha Phosphorylation |
|
| Relations |
| BioProject |
PRJNA1024997 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE244841_ER_E2Rln_repscomb.bw |
98.2 Mb |
(ftp)(http) |
BW |
| GSE244841_ER_E2_repscomb.bw |
99.7 Mb |
(ftp)(http) |
BW |
| GSE244841_ER_Rln_repscomb.bw |
98.4 Mb |
(ftp)(http) |
BW |
| GSE244841_ER_Veh_repscomb.bw |
96.6 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K27ac_E2Rln_rep12comb.bw |
29.3 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K27ac_E2_rep12comb.bw |
29.3 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K27ac_Rln_rep12comb.bw |
29.3 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K27ac_Veh_rep12comb.bw |
29.3 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K4me1_E2Rln_rep12comb.bw |
90.7 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K4me1_E2_rep12comb.bw |
91.4 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K4me1_Rln_rep12comb.bw |
93.3 Mb |
(ftp)(http) |
BW |
| GSE244841_H3K4me1_Veh_rep12comb.bw |
96.2 Mb |
(ftp)(http) |
BW |
| GSE244841_Input_E2Rln_repscomb.bw |
99.9 Mb |
(ftp)(http) |
BW |
| GSE244841_Input_E2_repscomb.bw |
95.0 Mb |
(ftp)(http) |
BW |
| GSE244841_Input_Rln_repscomb.bw |
95.6 Mb |
(ftp)(http) |
BW |
| GSE244841_Input_Veh_repscomb.bw |
98.1 Mb |
(ftp)(http) |
BW |
SRA Run Selector |
| Raw data are available in SRA |
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