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| Status |
Public on Dec 31, 2011 |
| Title |
Neurological defects in CAIX knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To further identify transcriptomic responses to CAIX deficiency in the brain, genome-wide cDNA microarray analyses were performed. Thirty-one and 37 genes were up- and down-regulated in the brain of Car9-/- mice as compared to wild-type mice. Functional annotation revealed that genes with increased expression are mainly involved in alternative splicing, nucleotide binding, RNA binding, and regulation of cellular protein metabolic process; whereas genes with reduced expression are chiefly implicated in cellular cation homeostasis, positive regulation of ion transport, Ubl conjugation, phosphorus metabolic process, and regulation of cell proliferation. Notably, the biological processes behaviour and locomotory behaviour are two prominent over-representation terms among the down-regulated genes, which is consistent with the results obtained from behavioural tests.
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| Overall design |
Brain tissue samples were collected from five wild-type and four CAIX KO mice, respectively, at the age of eight months. Total RNAs were purified and used for cDNA microarray.
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| Contributor(s) |
Pan P, Parkkila A, Järventausta S, Hilvo M, Pastorekova S, Pastorek J, Parkkila S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 09, 2010 |
| Last update date |
Apr 18, 2012 |
| Contact name |
Pei-wen Pan |
| Organization name |
Institute of Medical Technology, University of Tampere
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| Street address |
Biokatu 6
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| City |
Tampere |
| ZIP/Postal code |
33520 |
| Country |
Finland |
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| Platforms (1) |
| GPL4055 |
Sentrix Mouse-6 Expression BeadChip |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA130253 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24051_non-normalized.txt.gz |
2.2 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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