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| Status |
Public on Mar 10, 2005 |
| Title |
Murine Rat Brain Injury |
| Organisms |
Mus musculus; Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Summary: Brain trauma is a major cause of morbidity and mortality, both in adult and pediatric populations. Much of the functional deficit derives from delayed cell death resulting from induction of neurotoxic factors that overwhelm endogenous neuroprotective responses.
Hypothesis: Gene expression profiling across species and models may help identify candidate molecular pathways induced by brain injury, some of which may provide novel targets for therapeutic intervention.
Specific Aim: To identify the potential molecular mechanisms underlying such delayed responses, we compared gene expression patterns using high-density oligonucleotide arrays at 4, 8, 24 and 72 hours after moderate levels of lateral fluid percussion-induced brain injury in rats and lateral controlled cortical impact injury in mice.
Keywords: other
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| Contributor(s) |
Natale J |
| Citation(s) |
14588109 |
| Submission date |
Mar 09, 2005 |
| Last update date |
Oct 01, 2019 |
| Contact name |
Eric P Hoffman |
| E-mail(s) |
ericphoffman@gmail.com
|
| Organization name |
Binghamton University - SUNY
|
| Department |
Pharmaceutical Sciences
|
| Street address |
PO Box 6000
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| City |
Binghamton |
| State/province |
NY |
| ZIP/Postal code |
13902 |
| Country |
USA |
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| Platforms (2) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (61)
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| Relations |
| BioProject |
PRJNA91203 |
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