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| Status |
Public on Feb 14, 2024 |
| Title |
Laser Capture Microdissection Provides a Novel Molecular Profile of Human Primary Cutaneous Melanoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Melanoma accounts for the majority of skin cancer related mortality. In-depth molecular analysis of neoplastic melanocytes in whole tissue biopsies is diluted by the inflammatory infiltration, which may obscure gene signatures specific to neoplastic cells. Thus, a method is needed to precisely uncover molecular changes specific to tumor cells from a limited sample of primary melanomas.
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| Overall design |
We performed laser capture microdissection (LCM) and gene expression profiling of patient-derived frozen sections of pigmented lesions and primary cutaneous melanoma.
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| Contributor(s) |
Krueger J, Navrazhina K, Williams S, Garcet S |
| Citation(s) |
37776566 |
| Submission date |
Jul 25, 2023 |
| Last update date |
Feb 15, 2024 |
| Contact name |
James Krueger |
| E-mail(s) |
kruegej@rockefeller.edu
|
| Phone |
212-327-7730
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| Organization name |
The Rockefeller University
|
| Department |
Center for Clinical and Translational Science
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| Lab |
Laboratory of Investigative Dermatology
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| Street address |
1230 York Avenue
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA998372 |
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