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| Status |
Public on Jul 01, 2023 |
| Title |
The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Emodin (EMO), a natural derivative of the anthraquinone family mainly extracted from rhubarb (Rheum palmatum), has previously been demonstrated to possess superior anti-inflammatory properties from a single target or pathway. In order to explore the underlying mechanism of action of EMO against rheumatoid arthritis (RA), a network pharmacology approach was employed.
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| Overall design |
We then designed three samples as the intervention group (D) and three as the control group (T).
Comparative gene expression profiling analysis of RNA-seq data for intervention group and control group
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37324499/
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| |
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| Contributor(s) |
Cao C, Rong X |
| Citation(s) |
37324499 |
| Submission date |
May 17, 2023 |
| Last update date |
Jul 31, 2023 |
| Contact name |
chunhao cao |
| E-mail(s) |
CHUNHAO@hkbu.edu.hk
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| Organization name |
Hong Kong Baptist University
|
| Department |
School of Chinese Medicine
|
| Street address |
Hong Kong
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| City |
Hong Kong |
| ZIP/Postal code |
999077 |
| Country |
Hong Kong |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA973570 |
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