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| Status |
Public on Mar 18, 2011 |
| Title |
Genome-wide analysis of time-dependent gene expression in MCF-10A cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Results of blocking HER-2 kinase activity in MCF-10A cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these nontransformed breast epithelial cells.
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| Overall design |
MCF-10A cells were treated with the HER-2-specific small molecule kinase inhibitor CP724,714 for 45 hours. Total RNA was collected every 3 hours from parallel cultures throughout the 45 hour duration of treatment and genome-wide analysis of expression was performed on RNA from each time point (total 16 time points, starting at 0 hours treatment).
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| Contributor(s) |
Bollig-Fischer A, Ethier SP |
| Citation(s) |
21437235, 25028721 |
| Submission date |
Jul 25, 2010 |
| Last update date |
Sep 11, 2014 |
| Contact name |
Aliccia B Bollig-Fischer |
| E-mail(s) |
bollig@karmanos.org
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| Organization name |
Karmanos Cancer Inst., Wayne State University
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| Street address |
4100 John R, HWCRC rm 815
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| City |
Detroit |
| State/province |
MI |
| ZIP/Postal code |
48201 |
| Country |
USA |
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| Platforms (1) |
| GPL6255 |
Illumina humanRef-8 v2.0 expression beadchip |
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| Samples (16)
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| GSM569994 |
CP724,714-treated_MCF10A_9hour |
| GSM569995 |
CP724,714-treated_MCF10A_12hour |
| GSM569996 |
CP724,714-treated_MCF10A_15hour |
| GSM569997 |
CP724,714-treated_MCF10A_18hour |
| GSM569998 |
CP724,714-treated_MCF10A_21hour |
| GSM569999 |
CP724,714-treated_MCF10A_24hour |
| GSM570000 |
CP724,714-treated_MCF10A_27hour |
| GSM570001 |
CP724,714-treated_MCF10A_30hour |
| GSM570002 |
CP724,714-treated_MCF10A_33hour |
| GSM570003 |
CP724,714-treated_MCF10A_36hour |
| GSM570004 |
CP724,714-treated_MCF10A_39hour |
| GSM570005 |
CP724,714-treated_MCF10A_42hour |
| GSM570006 |
CP724,714-treated_MCF10A_45hour |
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| This SubSeries is part of SuperSeries: |
| GSE23176 |
Oncogene activation induces metabolic transformation resulting in insulin independence in human breast cancer cells |
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| Relations |
| BioProject |
PRJNA133243 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE23138_non-normalized.txt.gz |
2.2 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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