|
| Status |
Public on Nov 13, 2023 |
| Title |
Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the results of bulk RNA-seq from human Hürthle cell carcinoma (HCC) samples and matched normal thyroids. The bulk RNA-seq data reveals the molecular programs that are activated in HCC. These activated programs include mTOR and Myc signaling, the mitochondrial unfolded protein response, lipid peroxide scavenging, and amino acid biosynthesis.
|
| |
|
| Overall design |
Bulk RNA-seq in human Hürthle cell carcinoma (n=24) and matched normal thyroid (n=18) samples.
|
| |
|
| Contributor(s) |
Mootha VK, Parangi S, Gopal RK |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 03, 2023 |
| Last update date |
Nov 13, 2023 |
| Contact name |
Vamsi Mootha |
| Organization name |
Broad Institute
|
| Street address |
415 Main Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (42)
|
|
| Relations |
| BioProject |
PRJNA951766 |
Less...
More...