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Series GSE22035 Query DataSets for GSE22035
Status Public on Jan 10, 2011
Title Gene expression data in estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERα-positive breast tumors PIK3CA mutations have been observed in 30% to 40%. However, genes expressed in connection to the pathway activation in breast tumorigenesis remain largely unknown.
To identify downstream relevant target genes (and signaling pathways) turned on by the aberrant PI3K/AKT signal in breast tumors, we analyzed gene expression by pangenomic oligonucleotide microarray in a series of 43 ERα-positive tumors with and without PIK3CA mutations.
 
Overall design 43 ERα-positive breast tumors including 14 tumors with PIK3CA mutations and 29 tumors without PIK3CA mutattions were used as screening set for microarray.
 
Contributor(s) Cizkova M, Cizeron-Clairac G, Vacher S, Susini A, Andrieu C, Marisa L, de Reyniès A, Lidereau R, Bièche I
Citation(s) 21209903
Submission date May 27, 2010
Last update date Mar 25, 2019
Contact name clairac geraldine
E-mail(s) clairac@crh1.org
Phone 33147112310
Fax 33147111696
Organization name Centre Rene Huguenin
Department Oncogenetique
Lab INSERM U735
Street address 35 rue Daily
City SAINT-CLOUD
ZIP/Postal code 92210
Country France
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (43)
GSM547768 Normal-ERα-positive breast cancer 2
GSM547769 Normal-ERα-positive breast cancer 3
GSM547770 Normal-ERα-positive breast cancer 4
Relations
BioProject PRJNA128895

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22035_RAW.tar 312.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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