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| Status |
Public on Jan 17, 2024 |
| Title |
Gene expression data of colorectal cancer patient-derived cells treated with tankyrase inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Tankyrase, a poly(ADP-ribose) polymerase family member, regulates multiple cellular processes. Tankyrase inhibitors efficiently suppress colorectal cancer (CRC) cell proliferation. To examine the mechanism of anti-proliferative effect of tankyrase inhibitors (G007LK and RK582), we analyzed gene expression profiles of patient-derived CRC cells (JC11 and JC494) left untreated or treated with 0.3 µM G007LK or RK582 for 24 h by cDNA microarray analysis.
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| Overall design |
The patient-derived CRC cells, JC11 and JC494, were left untreated (DMSO) or treated with 0.3 µM G007LK or RK582 for 24 h. After the treatment, cells were collected and then gene expression data were obtained.
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| Contributor(s) |
Chen M, Mashima T, Muramatsu Y, Shirai F, Nagayama S, Katayama R, Seimiya H |
| Citation(s) |
37968472 |
| Submission date |
Nov 10, 2022 |
| Last update date |
Jan 18, 2024 |
| Contact name |
Tetsuo Mashima |
| E-mail(s) |
ttmjmj@gmail.com
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| Phone |
81-3-3520-0111
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| Organization name |
Japanese Foundation for Cancer Research
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| Department |
Cancer Chemotherapy Center
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| Lab |
Division of Molecular Biotherapy
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| Street address |
Koto-ku, Ariake 3-8-31
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| City |
Tokyo |
| ZIP/Postal code |
135-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA900266 |
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