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| Status |
Public on Aug 17, 2022 |
| Title |
RNAseq analysis of primary astrocyte and microglia under Aβ40WT and Aβ42WT fibrils treatment |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the influence of Aβ40WT and Aβ42WT fibrils on astrocyte and microglia, we isolated astrocyte and microglia from P2 SD rats and treated glia cells with Aβ40WT and Aβ42WT fibrils for 24 hours.
We then performed gene expression profiling analysis using data obtained from RNA-seq of astrocyte and microglia treated with Aβ fibrils.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for primary astrocyte and microglia under the treatment of Aβ40WT and Aβ42WT fibrils
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| Contributor(s) |
Zhu X, Van Nostrand W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 14, 2022 |
| Last update date |
Aug 20, 2022 |
| Contact name |
Willam Van Nostrand |
| E-mail(s) |
wvannostrand@uri.edu
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| Organization name |
University of Rhode Island
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| Department |
College of Pharmacy
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| Lab |
360
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| Street address |
7 Greenhouse Rd
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| City |
Kingston |
| State/province |
Rhode Island |
| ZIP/Postal code |
02881 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (18)
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| GSM6456030 |
Primary astrocyte, Aβ42_01 |
| GSM6456031 |
Primary astrocyte, Aβ42_02 |
| GSM6456032 |
Primary astrocyte, Aβ42_03 |
| GSM6456033 |
Primary astrocyte, Aβ40_01 |
| GSM6456034 |
Primary astrocyte, Aβ40_02 |
| GSM6456035 |
Primary astrocyte, Aβ40_03 |
| GSM6456036 |
Primary microglia, control_01 |
| GSM6456037 |
Primary microglia, control_02 |
| GSM6456038 |
Primary microglia, control_03 |
| GSM6456039 |
Primary microglia, Aβ42_01 |
| GSM6456040 |
Primary microglia, Aβ42_02 |
| GSM6456041 |
Primary microglia, Aβ42_03 |
| GSM6456042 |
Primary microglia, Aβ40_01 |
| GSM6456043 |
Primary microglia, Aβ40_02 |
| GSM6456044 |
Primary microglia, Aβ40_03 |
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| Relations |
| BioProject |
PRJNA869461 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE211198_RAW.tar |
1.5 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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