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Series GSE206285 Query DataSets for GSE206285
Status Public on Aug 08, 2022
Title Efficacy and safety of ustekinumab treatment in patients with ulcerative colitis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary UNIFI was a randomized placebo-controlled phase 3 clinical trial evaluating the efficacy and safety of ustekinumab (ClinicalTrials.gov Identifier: NCT02407236). Gene expression profiling by microarrays was carried out at baseline on biopsies from the sigmoid colon (15-20cm from anal verge) of patients (n=550) with moderate-to-severe ulcerative colitis and of healthy subjects (n=18). Ulcerative colitis patients received placebo (n=186) or ustekinumab (n=364). The effects of two different dosages were investigated: 130mg (n=180) and 6mg/kg (n=184).
 
Overall design Patients with moderate-to-severe ulcerative colitis were treated with ustekinumab (n=364) or placebo (n=186) at week 0. Biopsy samples were collected from 550 patients and 18 healthy subjects at baseline for RNA extraction and microarray profiling.
 
Contributor(s) Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo J, Alberts E, Costa Sa AC, Niazi U, Friedman J, Long A, Ding Y, Carey C, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, MacDonald T, Lord G, Bewick G, Powell N
Citation(s) 36192482, 36170836, 36109152
Submission date Jun 16, 2022
Last update date Mar 15, 2024
Contact name Nick Powell
E-mail(s) npowell@ic.ac.uk
Organization name Imperial College London
Department Department of Metabolism, Digestion and Reproduction
Street address Du Cane Road
City London
ZIP/Postal code W12 0NN
Country United Kingdom
 
Platforms (1)
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
Samples (568)
GSM6249277 CNTO1275UCO3001-100001 colon biopsy week 0
GSM6249278 CNTO1275UCO3001-100002 colon biopsy week 0
GSM6249279 CNTO1275UCO3001-100003 colon biopsy week 0
Relations
BioProject PRJNA849958

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE206285_RAW.tar 1.1 Gb (http)(custom) TAR (of CEL)
GSE206285_additional_sample_metadata.tsv.gz 8.2 Kb (ftp)(http) TSV
Processed data included within Sample table
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