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| Status |
Public on May 15, 2024 |
| Title |
Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The more aggressive clinical disease course of Pediatric Onset Multiple Sclerosis(POMS) as compared to Adult Onset Multiple Sclerosis(AOMS) during the first year disease is supported by higher inflammatory potential promoted by transcriptional level of age-associated genes and transcription factors involved in Cell Cycle, B Cell proliferation and senescent mechanisms.
Herein, we compared the blood mononuclear cell transcriptome of POMS and AOMS patients during first year disease. Pediatric Healthy and Adult subjects (PHC, AHC) were used as controls. Correlation analysis of the gene expression with the radiological sign, upstream regulators analysis and clinical assesment were also evaluated.
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| Overall design |
A total of 38 MS patients (22 POMS and 16 AOMS) and 21 Healthy controls( 11 PHC and 10 AHC) were analyzed.
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| Contributor(s) |
Shavit E, Menascu S, Achiron A, Gurevich M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 18, 2022 |
| Last update date |
May 15, 2024 |
| Contact name |
Michael Gurevich |
| E-mail(s) |
Michael.Gurevich@sheba.health.gov.il
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| Organization name |
Sheba Medical Center
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| Department |
Multiple Sclerosis Center
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| Lab |
Neurogenomics and Neuroimmunology
|
| Street address |
Tel Hashomer
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| City |
Ramat Gan |
| ZIP/Postal code |
52621 |
| Country |
Israel |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (59)
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| Relations |
| BioProject |
PRJNA839242 |
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