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| Status |
Public on Aug 31, 2022 |
| Title |
Human patients with influenza virus and bacterial infections |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Peripheral blood was collected from human patients infected with influenza A virus only or in addition with bacterial pathogens and at different days after hospital admission. For comparison, blood from healthy controls was collected. Gene expression differences were detected in influenza and bacterial infections compared to healthy controls, and at various days post infection.
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| Overall design |
We recruited patients from 20 hospitals during the period 2009 to 2016. The eligibility criteria included (1) age greater than 18 years and (2) World Health Organization definition of influenza-like illness (fever of 38 C° or higher, cough and illness onset within the last ten days). Eligible patients were assessed by an admitting physician for likelihood of influenza infection. Patients with a high likelihood of infection, based on history and clinical features, were enrolled into the study. Collection of peripheral blood from human patients, preparation of RNA and gene expression analysis using microarrays was performed.
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| Contributor(s) |
Schughart K, Tang B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 08, 2021 |
| Last update date |
Sep 02, 2022 |
| Contact name |
Klaus Schughart |
| E-mail(s) |
labschughart@online.de
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| Phone |
+49-159-0483-7911
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| Organization name |
University Münster
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| Department |
Virology
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| Street address |
Von-Esmarch-Str 56
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| City |
Münster |
| ZIP/Postal code |
48149 |
| Country |
Germany |
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| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
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| Samples (152)
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| Relations |
| BioProject |
PRJNA769705 |
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