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Status |
Public on Jan 12, 2021 |
Title |
Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Background: Mast cells play an important role in allergic responses and persistently exposure to environmental fine particulate matter (PM2.5) exacerbates allergic diseases,but the details remain elucidative. Conclusions: PM2.5 regulates ROS production through Gadd45b/MEKK4/JNK pathway, facilitating IgE-mediated mast cell activation.
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Overall design |
RBL-2H3 cell with Normal saline and PM2.5 plus IgE+DNP-HSA
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Contributor(s) |
Wang Y, Tang N |
Citation missing |
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Submission date |
Jan 11, 2021 |
Last update date |
Jan 12, 2021 |
Contact name |
Ying Wang |
E-mail(s) |
xywying@csu.edu.cn
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Organization name |
Xiangya Hospital
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Street address |
Xiangya Road
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City |
Changsha |
ZIP/Postal code |
410000 |
Country |
China |
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Platforms (1) |
GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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Samples (2) |
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Relations |
BioProject |
PRJNA691150 |
SRA |
SRP301211 |