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| Status |
Public on Aug 24, 2020 |
| Title |
Blast-related mild TBI alters anxiety-like behavior and transcriptional signatures in the rat amygdala |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Male Long Evans rats aging 10-12 weeks were exposed to repeated blast overpressure and then went through behavioral tests for anxiety and fear conditioning. After 1-1.5 months (sub-acute) or 12-13 months (chronic), amygdala tissue specimens from all animals were collected. RNA-seq was used to measure transcriptome-wide gene expression of sham and blast animals at different timepoints. The study identified changes in the amygdalar transcriptome and associated anxiety-related phenotypic outcomes related to both blast exposure and aging, which may play a role in the long-term pathological consequences of mTBI.
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| Overall design |
RNA-seq profiling of sham and blast-exposed rats at different time points distal to blast injury.
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| Contributor(s) |
Blaze J, Wang Z, Haghighi F |
| Citation(s) |
33192359 |
| Submission date |
Jul 29, 2020 |
| Last update date |
Nov 23, 2020 |
| Contact name |
Fatemeh Haghighi |
| E-mail(s) |
fatemeh.haghighi@mssm.edu
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Department |
Neuroscience
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| Lab |
Haghighi Lab
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| Street address |
1425 Madison Ave, 9-20D
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (62)
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| Relations |
| BioProject |
PRJNA649566 |
| SRA |
SRP274156 |
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