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| Status |
Public on Apr 10, 2020 |
| Title |
Eye-antenna early L3 disc expression profiling in COX7a-LoF and Notch-GoF |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression in larval, early third instar eye-antenna discs was assesed in genotypes with Notch Gain-of-Function (UAS-Delta or UAS-Notch[intra2]) over-expression or mitochondrial COX7a Loss-of-function (UAS-COX7a-RNAi) or a combination of both (UAS-Delta, UAS-COX7a-RNAi). The analysis revealed that, despite a strong genetic interaction between Notch pathway activation and knockdown of COX7a, no transcriptional cooperation or synergy was detectable in early L3 eye-antenna discs. Rather, COX7a knockdown induced a unique transcriptional signature, which further experiments revealed to be mediated by the transcription factor ATF4.
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| Overall design |
Two biological replicates for five genotypes were analysed (ten samples in total)
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| Contributor(s) |
Sorge S, Theelke J, Yildirim K, Hertenstein H, McMullen E, Müller S, Altbürger C, Schirmeier S, Lohmann I |
| Citation(s) |
32433968 |
| Submission date |
Apr 09, 2020 |
| Last update date |
Aug 13, 2020 |
| Contact name |
Sebastian Sorge |
| E-mail(s) |
sebastian.sorge@crick.ac.uk
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| Organization name |
The Francis Crick Institute
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| Street address |
1 Midland Road
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| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA624146 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148407_RAW.tar |
21.6 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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