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| Status |
Public on Dec 10, 2019 |
| Title |
Gene expression in PC3 cells(human prostate cancer cell line) upon HIC1 knockout |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To explore the role of HIC1 deletion in regulating prostate cancer(PCa) microenvironment development, Human Gene Expression Microarrays were searched for altered genes upon HIC1 knockout expression in PC3 cells. According to fold-change screening between HIC1-knockout and its respective control cells, both up-regulated and down-regulated genes were shown.
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| Overall design |
Human PCa cell line PC3 was transfected with Lenticas9-blast and the sgRNA expression plasmid Lentiguid-puro (sgRNA targeting HIC1 and respective control). HIC1-knockout cells were respectively noted as PC3 sgHIC1. Their respective control cells were respectively noted as PC3 Ctrl.
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| Contributor(s) |
Wu T, Wang J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 09, 2019 |
| Last update date |
Dec 12, 2019 |
| Contact name |
Tianqi Wu |
| E-mail(s) |
395307534@qq.com
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| Phone |
+86 13951905910
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| Organization name |
Fudan University Shanghai Cancer Center
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| Department |
Cancer institute
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| Street address |
No.270 Dong'an Road
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA594285 |
